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Appendix 1
Search strategies and words used in to answer the clinical
questions:
PICO 1
What are the diagnostic criteria for chronic myeloid leukemia?
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive OR
Leukemia, Myeloid, Philadelphia-Positive OR Leukemia,
Granulocytic, Chronic OR Myeloid Leukemia, Chronic OR
Chronic Myeloid Leukemia OR Leukemia, Myelocytic,
Chronic OR Chronic Myelocytic Leukemia OR Leukemia,
Myelogenous, Chronic OR Myelogenous Leukemia,
Ph1-Positive OR Leukemia, Myeloid, Ph1 Positive OR
Myelogenous Leukemia, Chronic OR Myeloid Leukemia,
Philadelphia-Positive OR Granulocytic Leukemia, Chronic
OR Leukemia, Myeloid, Chronic, Atypical, BCR-ABL
Negative) AND (classification OR criteria OR World Health
Organization* OR standards*) AND (sensitiv*[Title/
Abstract] OR sensitivity and specificity[MeSH Terms] OR
diagnos*[Title/Abstract] OR diagnosis[MeSH:noexp] OR
diagnostic * [MeSH:noexp] OR diagnosis,differential[MeSH
:noexp] OR diagnosis[Subheading:noexp])
PICO 2
Is there any difference in the prognosis of CML patients
with p210, e13a2(b2a2) and e14a2(b3a2) or (e1a2)p190
rearrangements?
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive OR
Leukemia, Myeloid, Philadelphia-Positive OR Leukemia,
Granulocytic, Chronic OR Myeloid Leukemia, Chronic OR
Chronic Myeloid Leukemia OR Leukemia, Myelocytic, Chronic
OR Chronic Myelocytic Leukemia OR Leukemia, Myelogenous,
Chronic ORMyelogenous Leukemia, Ph1-Positive ORLeukemia,
Myeloid, Ph1 Positive OR Myelogenous Leukemia, Chronic
OR Myeloid Leukemia, Philadelphia-Positive OR Granulocytic
Leukemia, Chronic) AND ((Fusion Proteins, bcr-abl AND
genetics*) OR p210 OR e13a2 OR b2a2 OR e14a2 OR
b3a2 OR p190 OR e1a2 OR Isoform*) AND (prognos*[Title/
Abstract] OR (first[Title/Abstract] AND episode[Title/Abstract])
OR cohort[Title/Abstract])
PICO 3
At diagnosis, do the Philadelphia chromosome and the 9q
deletion have prognostic significance?