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Neonatal screening in the state of Piaui: an urgent need - a study on the prevalence of sickle cell disease in newborns
Rev Bras Hematol Hemoter. 2012;34(5):392-3
Tests to detect hemoglobins were carried out using high-
performance liquid chromatography (HPLC) and the Variant II
(BioRad) system.
On including hemoglobinopathies in the PNTN, the Ministry
of Health took an important step towards acknowledging the
relevance of the matter to public health in Brazil.
Adorno et al. reported the prevalence of variant hemoglobins
in 590 newborns in the city of Salvador; 0.2% for Hb FS and
0.9% for Hb FSC, thus demonstrating the high rate of sickle cell
disease in the population, as well as the high prevalence (9.8%)
of the sickle disease trait
(6)
. The city of Teresina registered rates
of 0.5% for Hb FS and 3.8% for Hb FAS.
A 2006 survey by Pinheiro et al. of 389 newborns in the city
of Fortaleza registered figures of 0.2% for Hb SS and 3.8% for Hb
AS
(8)
. A survey conducted of 1903 newborns in the city of Natal
revealed a prevalence of only 0.05% for Hb SS and 1.5% for Hb
AS
(7)
. The city of Teresina registered 0.5% of Hb FS and 3.8% of
Hb FAS, a fact which may be explained by the fact that the state
of Piauí has a significantly high black population.
These figures reflect need for the immediate implementation
of phase II of the PNTN in the state of Piauí and the creation of a
multi-disciplinary care network for sickle cell patients.
References
1. Brasil. Ministério da Saúde. Departamento de Apoio à Gestão
Participativa. Seminário Nacional de Saúde da População Negra
[Internet]. Brasília: MS; 18 a 20 agosto de 2004. [cited 2012 Jul 30].
Available from: http://portal.saude.gov.br/portal/arquivos/pdf/caderno_
textos_basicos_snspn.pdf
2. Laguardia J. No fio da navalha: anemia falciforme, raça e as implicações
no cuidado à saúde. Rev Est Feministas. [Internet] 2006 [cited 2012 Jan
12];14(1):243-62. Available from: http://www.redalyc.org/src/inicio/
ArtPdfRed.jsp?iCve=38114113
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Available from: http://bvsms.saude.gov.br/bvs/publicacoes/0081.pdf
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5. Steinberg MH. Sickle cell anemia, the first molecular disease: overview
of molecular etiology, pathophysiology, and therapeutic approaches. S
cientific World J. 2008;8:1295-324.
6. Adorno EV, Couto FD, Moura Neto JP, Menezes JF, Rêgo M, Reis MG,
et al. Hemoglobinopathies in newborns from Salvador, Bahia, Northeast
Brazil. Cad Saúde Pública. 2005;21(1):292-8.
7. deAraújo MC, Serafim ES, de Castro Jr WA, de Medeiros TM. [Prevalence
of abnormal hemoglobins in newborns in Natal, Rio Grande do Norte,
Brazil]. Cad Saude Publica. 2004;20(1):123-8. Portuguese.
8. Pinheiro LS, Gonçalves RP, Tomé CA, Alcântara AE, Marques AR, Silva
MM. Prevalência de hemoglobina S em recém nascidos de Fortaleza:
importância da investigação neonatal. Rev Bras Ginecol Obstet.
2006;28(2):122-5.
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